Running out of helium!
In 25 years? Oh my gosh, how will I make a squeaky voice at my grandchild's birthday party?
BTW, nothing is ever said about weightlessness in this article. You don't achieve weightlessness, even in the ISS, unless you are perpetually falling toward earth. If the ISS held perfectly steady above the earth the astronauts would still experience gravity. Think about it... the mere fact that the ISS and other satellites are orbiting the earth means that they are experiencing gravity.