Shift of manufacturing economics - material and components not in paradigm.
3-D printing will need very highly refined component materials (metals, plastics, ceramics, etc.) for the specific respective printing processes. Economics of refining the required special 3-D printing materials, energy and the transportation of those products will dictate the most economically attractive locations for 3-D printing- sans labor cost. Technology is the most portable commodity there is. The assertion that 3-D printing will bring jobs and business back to the US is provably erroneous and disappointingly naive.