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    <title><![CDATA[Discussion on Top 10 genetic findings of 2010 ]]></title>
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    <item>
        <title><![CDATA[Not sequencing!]]></title>
        <link><![CDATA[http://www.smartplanet.com/forum/discussions/1-5091-39574]]></link>
        <description><![CDATA[Boonsri had a great article in Discover on this (glad to see the link).  One quick quibble: 23andMe does not sequence genomes (yet).  They use arrays to quickly test for presence/absence of SNPs.  This limits their approach to discovering only alleles that they know of, only in regions that they focus on.  So Church's rare alleles will go completely missed.  And given that most GWAs are only finding a handful of associations between phenotype and a common SNP that explains a very minor amount of heritability, it's likely that multiple rare alleles are the real culprits we would be interested in.  Which sucks, because that means that every unhappy disease is unhappy due to its own genetic defect (to paraphrase Tolstoy).]]></description>
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        <dc:creator><![CDATA[scottieb3]]></dc:creator>
        <pubDate>Fri, 08 Apr 2011 10:29:37 -0700</pubDate>
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        <title><![CDATA[RE: Top 10 genetic findings of 2010]]></title>
        <link><![CDATA[http://www.smartplanet.com/forum/discussions/1-5091-33988]]></link>
        <description><![CDATA[Thanks for an insightful article on genetic ancestry. Your extended piece on the Discovery Magazine site was also well-written and a curiosity generating bonus.]]></description>
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        <dc:creator><![CDATA[SimInfo]]></dc:creator>
        <pubDate>Fri, 14 Jan 2011 09:06:05 -0800</pubDate>
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