Enhancements
I see external enhancements as interesting with a lot of potentials. As it stands, limitations on computers make is such that a combination of human and machine is the most capable force. Be careful competing with machines directly though. They will win. always do what humans do best and use machines as tools.
I would recommend against any stimulant drugs. In the 70's it was "speed kills", then cocaine, then speed again, then crank, then ice and now bath salts. One thing about stimulants, it just seems that they make you crazy. Another problem along that line is that anything you start, you eventually have to quit. If we can't make it as we are, what are we making ourselves and why? What do you want to achieve? I'm a stimulant junkie. Not chemicals, but the excitement of sport, story and experience. I program and am addicted to the challenge and stimulation of my job. I go through withdrawals when I complete a project. Of course there is a downside. I am tough, blessed with uncommon strength and endurance. That endurance and strength relates to hormones. It is quite likely to kill me. I have to work to make sure that I keep the stimulation level below what releases hormones into my system. I see a definite potential danger to the stimulation level this society/culture can provide with no drugs. I think using drugs to increase stimulation as very dangerous.