Nature's Secret Weapon: Super Pandemic(s)
Once the overdue pandemic(s) take off, especially as antibiotic resistance grows faster than already rapid and super dangerous Climate Change that will release unimaginable amounts of methane into the atmosphere, cities will become pandemic breeding pens.
That will turn cities, towns and villages into decaying ghost towns and rural regions into battle fields where the by then savage remnants of humanity slaughter each other for whatever edible plants are still reasonably safe to eat, since agriculture has also set itself up for mutating pandemics specific to vegetation.
Like the business cycle, life too has a cycle, and we are on the verge of the big, very, very big crash.
The upside is that after a cyclic crash, there is always a rebirth of sorts. Unfortunately, like mammals replacing dinosaurs, the rebirth is unlikely to include us -- at least not at the top of the, ummm, food chain.