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Scientists suggest clinical potential for psychedelic drugs

By | August 20, 2010, 8:43 AM PDT

Psychedelic drugs such as LSD, ketamine or magic mushrooms could help treat people suffering from depression, compulsive disorders or chronic pain.

Mind-altering recreational drugs have always gotten a bad rap, but new research indicates that they could be combined with psychotherapy for clinical use.

Swiss researchers conducting brain imaging studies at the University of Zurich found that psychedelics such as LSD (lysergic acid diethylamide), ketamine and psilocybin — the “magic” part of “magic mushrooms” — affect the brain in such as a way that they could help reduce symptoms of psychiatric disorders.

Yes, you read that right: mind-altering drugs can help patients alter their perception of pain levels.

Far out, dude.

Key is the involvement of behavioral therapists or psychotherapists, which scientists say can help patients deep-dive into, say, suppressed memories. (Psychedelics have a wide range of effects, from freeing bliss to anxious paranoia.)

Researchers Franz Vollenweider and Michael Kometer of the university’s neuropsychopharmacology and brain imaging unit said that the drugs affect the brain’s neurotransmitter systems, which have been found to be different in people with clinical depression and anxiety.

But doses of psychedelics must be low and given in combination with therapy sessions to be effective, they said. They must only be given over a short time period, they said, and are best for patients who fail to respond to drugs called selective serotonin reuptake inhibitors, or SSRIs, on the market as Prozac or Paxil.

“These are serious, debilitating, life-shortening illnesses,” the researchers wrote, “and as the currently available treatments have high failure rates, psychedelics might offer alternative treatment strategies that could improve the well-being of patients and the associated economic burden on patients and society.”

Their research was published the journal Nature Neuroscience.

Photo, top: Coaster420/Wikipedia

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Andrew Nusca

About Andrew Nusca

Andrew Nusca is editor of SmartPlanet.

Andrew Nusca

Andrew Nusca

Editor

Andrew Nusca is editor of SmartPlanet and an associate editor for ZDNet. Previously, he worked at Money, Men's Vogue and Popular Mechanics magazines. He holds degrees from the Columbia University Graduate School of Journalism and New York University. He based in New York but resides in Philadelphia.

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Andrew Nusca

Andrew Nusca
Andrew Nusca does not hold any investments in the companies he covers.
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RE: Scientists suggest clinical potential for psychedelic drugs
Related: Vanity Fair just ran a story about LSD as part of psychotherapy treatment in Hollywood during the 1950s. Here's the link: http://www.vanityfair.com/hollywood/features/2010/08/drugs-in-hollywood-201008.
Posted by Christina Hernandez
20th Aug 2010
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This is news WHY?
These potential uses have been known for over 50 years, research has been slow due to government idiocy (redundant, I know.)

It would be NEWS if the governments suddenly decided to act reasonably and allow research.
Posted by wizoddg
20th Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
This sounds to me, to be nothing more than some drug company
trying to legitimize and expand their product lines. Aren't there
enough spooky people out, there waiting to go off heir prescribed
drugs, to kill a bunch of people. More nut cases wandering around,
one pill away from destruction, doesn't make me feel safe.
Posted by 16Tons
20th Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
This is as dangerous as it gets . The whole phycotherapy business is full of people with more problems than the people paying ( look at the % of $ spent in this part of "health Care" ) to see them . The oversight of this business is almost nonexistant . Having seen "shrinks"
I had to Educate (that one went To Harvard & does research now) ,
Comfort when I started talking about a problem I had she freaked and
was almost inconsolable to writing prescriptions at a level never before seen in history with almost Zero provable results . Look at most prescription drugs like Zoloft, Paxil ... against a Placebo and tell me these folks are policing their industry in any effective way . This is a VERY SAD JOKE NOW YOU Want to give people LSD ..
SEEMS the loony's are really running the Bin . I wouldn't let most Psychotherapists or psychiatrist wash my car . Well for 1 it would never be done . One of the Biggest scam's pulled in history. I will say sorry to the few that are actually competent and help people with measurable results , your paying for your industry turning America into a There is a pill for that nation . No NOt the Pharmaceutical Giants if the folks who perscribe looked they would know they do not work better than plecabo's and then not perscribe them. But that Mercedes and house @ the beach ... need to be paid for so well my time is up see you next week and oh by the way do you need your perscription renewed ? Most have a seperate inbox on the answering machines 4 this


SAD Professionals PLEASE Greedy Money grubbing folks who could give a **** whether you get better or not actually they don't make $ if you are well and never have to come back . So, What Do You Think They Would Prefer ?
Has Anyone ever been told "Hey you are well you don't need a prescription , endless "sessions" just buck up and DEAL with it ya wimp. Toughen up cupcake " Didn't think so !
Yes, lets let these folks lose with LSD . That is TRUE Insanity .
I will say I am sorry to the first normal "Shrink" . That right I will never ever have to utter those words to anyone from this "profession"
Posted by 1mikeyob
20th Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
It sound like they are going to try to "legelize" drugs as the marihuana in California for therapeutic uses. Those are old news in fact LSD was designed for those uses but it was inuseful and it become a "fun" drug as the others. See picture "Altered states" or read the Carlos Castaneda books and Maria Sabina's histories.
Posted by jorgeherrerapalafox
20th Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
If anyone wants to use drugs for any purpose (medical or recreational) it is their own business.

If someone is doing something in the privacy of their own home and not harming anyone else, who cares what they do?
Posted by Albee_Freeoneday
20th Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
Well....That's an "interesting" yet completely rambling diatribe
1mikeyob. I'm not surprised that you have seen several shrinks.
Exactly what did you educate them about? It certainly wasn't
spelling or putting together a cohesive argument. As far as your
alleged Zoloft vs placebo claim, exactly where did you get your
information from? By the way, exactly what was the point of
somehow comparing SSRI's vs placebos and tying it in to policing
of their industry?
As far as more pills being dispensed, that is true for about the
last 10-15 years. As different drugs are discovered/synthesized, it
is more efficient on numerous levels to have the patients, when
able, administer said drugs by mouth. I'm sorry that your
therapy(ies) didn't help you, but that shouldn't condemn an entire
field of medicine.
On to your next claim of "giving people LSD," you rant like they're
advocating LSD machines on street corners. The true fact is that
any serious research into the application of psychedelics in a
controlled psychotheraputic setting has been done outside of the
US since Nixon enacted reclassification of the drug schedules.
You might want to volunteer for one of those concerned with
paranoia and unresolved anger issues.
ps-make sure you wear you tin-foil hat outside!!
Posted by Datadad
20th Aug 2010
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<3
You're awesome, thanks for existing
Posted by Bothdylan
2nd Oct
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RE: Scientists suggest clinical potential for psychedelic drugs
Really? These comments are written so poorly that they look as though they are written by someone on drugs. If you can't construct sentences and paragraphs in a reasonable cohesive intelligible fashion then please stop annoying us. It's very painful to try and read and re-read comments that in the end serve no purpose but to torture the reader.
I say they should legalize LSD and other drugs. It can't be much worse than alcohol and the psychoactive brain killers be prescribed today!
Posted by Mr. G. Anson
20th Aug 2010
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This is a misunderstood issue.
First off without psychiatric drugs I would probably be dead. "thoughin up wimp" I'm glad you've never had any real problems buddy.
Most psychiatric drugs are amphetamines far more powerful than street drugs. You can learn the history from Alex Shulgan's PIKHAL and the story behind it.

The first research and trials of psychiatric drugs where done in Ontario in the 1930's since then all of the numerous asylums in the western world have been closed. If you want to confirm this use a real source of information like a university library not the internet to look it up.

On LSD specifically , a large part of the research on it's psychiatric value was done in the 1970's in Saskatoon Saskatchewan where I live. Those people were given the equivalent of hundreds of street doses and it mostly didn't work out so well. With that, the CIA trails and the 60's hippie movement this drug has been widely demonised even though it is quite safe physically and has always been believed to hold potential since the 1920's when it was discovered.

READ A BOOK
Posted by shaunehunter
20th Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
Ah, so I see you are finally catching up. What took you so long? Cheers, Len
Posted by cosmicfoole@...
20th Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
@Albee - I love the argument "If someone is doing something in the privacy of their own home and not harming anyone else, who cares what they do?"

Yeah, and who is paying the bill when those "not harming anyone else" need medical attention or are collecting from the government (ie taxpayers) when they can't hold down a job anymore.

Maybe my health care insurance wouldn't be so high if those "not harming anyone else" decided to quit smoking?
Posted by t0mmyt@...
20th Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
Just this week the Annals of Internal Medicine published a manuscript re: ketamine use for medication-resistant major depressive disorder. Studies such as the one presented in that article, and unlimited numbers of others from scholarly, peer-reviewed journals are how new treatments are brought into clinical use.
I suggest those who know nothing about that which they so quickly comment upon, should take the time to learn before adding their ignorant opinions.
Posted by kat313
20th Aug 2010
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This IS current and relevant - to those who understand.
Just this week the Annals of Internal Medicine published a manuscript re: ketamine use for medication-resistant major depressive disorder. Studies such as the one presented in that article, and unlimited numbers of others from scholarly, peer-reviewed journals are how new treatments are brought into clinical use.
I suggest those who know nothing about that which they so quickly comment upon, should take the time to learn before adding their ignorant opinions.
Posted by kat313
20th Aug 2010
0 Votes
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Where do all of me sign up?
all of us in me are interested, except one but all the rest of mes hold the majority.
Posted by dunn@...
20th Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
ttheys

"Yeah, and who is paying the bill when those "not harming anyone else" need medical attention or are collecting from the government (ie taxpayers) when they can't hold down a job anymore."

Well, you have just proven my point. They made a choice and they get the consequences. It is NOT your or my responsibility to support or pay for someone who does something that may be harmful to them, unless you or I requested they do it.

Please tell my morally why it is your or my responsibility to give handouts if we don't want to rewarding someone for choices they made?
Posted by Albee_Freeoneday
20th Aug 2010
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Part II
"Maybe my health care insurance wouldn't be so high if those "not harming anyone else" decided to quit smoking?"
True. And maybe it wouldn't be so high if:

1. The government would get out of creating all sorts of restrictions. HMO's were a great idea. Insure those who are healthy, maintain their health and give a lower rate. Then some really greedy envious people started screaming about how unfair it was that healthy people paid less. So government in it's infinite wisdom [sarcasm] decided HMO's had to open to everyone.
2. People could buy health insurance across state lines. Government won't let them.
3. Let you buy insurance for what you need. A single male does not need to buy insurance in case he gets pregnant, unless you go by government wisdom.
4. You and others took an insurance with a higher deductible, and paid minor things like doctor visits out of pocket.
5. Lawsuits were reigned in. Right now there are so many excessive tests taken for anything to protect against another frivolous lawsuit.
6. More people used alternative care (traditional Chinese Medicine, herbs, etc.)
Posted by Albee_Freeoneday
20th Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
Albee - quite frankly, I don't know what you're talking about. I don't know how I proved your point when the only thing you did was take the John Stuart Mills approach and say that if it isn't harming anyone else, who cares. I replied that it IS harming someone else.

So all I can guess is that you must be a frequent poster and either 1) I missed your sarcasm and those who typically post here frequently would know you were being sarcastic, or 2) you're mixing what you posted elsewhere with here.
Posted by t0mmyt@...
20th Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
It's been known for decades. The government has a mental block about research and practical use.
Posted by Aboleyn
20th Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
Without Paxil, Zoloft, Klonopin etc. many of us would never get out of the house because of depression, anxiety, panic disorder, PTSD and many other kinds of psychological problems. If scientists can find a way to use what are traditionally consider "hippie" or "recreational" drugs to help people go for it.
Posted by SEAL76
20th Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
I agree with these scientists, and since it's for science and all. I volunteer to be a test subject.
Posted by trust2112@...
20th Aug 2010
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Hmm...
"Psychedelic drugs such as LSD, ketamine or magic mushrooms could help treat people suffering from depression, compulsive disorders or chronic pain."

Isn't this why people use these drugs in the first place?
Posted by ddferrari
20th Aug 2010
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Suggestion
No the block was security, the US wanted to use the substances exclusively so they were put on a list and disinformation was used. The US has no mental block about their use of drugs, however they do not want to allow any other use as a matter of "security" whether this is in fact the case or not as in the case of investigation like MKULTRA and others etc etc where most of the data was subsequently destroyed, I suspect to protect the guilty. Perhaps now the light of day can shine on the darkness.
Posted by Altotus
20th Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
I can't see using Acid or Shrooms for this because of the time factor. 10-12 hours is way to long a time. Ketamine on the other hand is quite similar and would put the session into a more reasonable 1-2 hour period. It has been around for decades and
used on cats in surgery every day. Meow. Now while I have nothing against trails and colors, I would suggest hypnotheropy and Scopolamine for a more realistic altered reality.
Posted by zeprider1
20th Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
What a crock of horse pucky. These things aren't called "dope" for no reason. As for 'magic mushrooms - those are properly used only by Traditional spiritual people following strict specific dietary taboos during ceremony. Our People never used them for 'recreational / escapist' activities. Just another example of so-called researchers trying to find a way to legalize dope.
Posted by Indian.Maid
21st Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
@1mikeyob

LSD is one of the safest drugs ever manufactured... FAR safer than asprin, or caffeine... trouble is some stupid people have done stupid things (as stupid people tend to), like try to fly by jumping out of a window, or staring into the sun... the odds of lethal overdosing is virtually impossible barring, even at 98-168 hits (over 16000ug or 1mg), and even that will only make people and primates (70kg each) sluggish; and of course highly under the hallucinagenic effects, if you did that many pills of asprin you'd more than likely be dead, esspeciially when mixed with alcohol, with LSD alcohol actually has the exact opposite effect; it lessens the effect of LSD (and likewise LSD is also used to treat alcoholism. the lethal dose would be about 21 times more than that; or a 1/3 of a gram of pure LSD, at that point cardiac problems and muscle ridgitiy can because a cause of death....

like most drugs LSD got a bad rap after nixons drug war started esspecially for LSD and marijuana... in reality it would be PREFERABLE, by actual results, to use either or both to treat things that today are treated by drugs that have far more side effects than the problems they are supposed to be treating (esspecially things like depression). and even asprin; oddly enough LSD can also be used to treat cluster headaches (which effect 1 of every 1000 people)... you just don't want people on LSD driving or operating machinary... really not any worse than a drunk person... maybe alittle less annoying, and maybe likely much more insightful.. but most drunk people can barely think at all, so its not a fairr comparision to begin with... yet alcohol is legal.. and chances are you yourself drink it... and the lethal dose for alcohol is a mere 5 times the legal limit... again... something to consider when talking about how dangerous drugs are.


@Datadad

i'm sure he didn't know why, but he actually did have a point about the placebo's for most drugs to become approved (aside from general safety; toxicity) they only have have an effective rate 5% higher than the placebo in the blind and double blind testing... so in effect many drugs are baseically very expensive placebo's... but it should also be noted that placebo also work, which is usually attributed to the pyschosomatic effect via the person thinking the placebo is the real drug.


@ttheys@...

for one most drug users are responsible people for the most part; at least as much as people in general... generally if for nothing else than to get money to keep getting the drugs...

secondly, this would be by perscription, meaning if they had to be off work it would be the same as a person that can't work because of pain meds, or some medication that they needed that impaired their motor functions and/or significantly affecting their judgement.... or in a more broad sense, esspecially if its a permenant condition, then its akin to being disabled... would you then being against government support of the disabled, or for that matter anyone else who is UNABLE to work via a physical or mental condition.

as for your health insurance... maybe your health insurance wouldn't be so high if whatever country you live in joined the rest of the developed world and had some form of universal healthcare as to not be at the whim of the extortionists that tend to otherwise run healthcare... and FYI smokers (and drinkers) pay a tax which is supposed to help pay for their furture health costs.


@albee_freeoneday

1. actually people were complaining about a) being refused coverage via a pre-existing condition and b) having their coverage canceled, just because they actually needed to use it... and yes healthcare in the US is VASTLY overpriced, partly because of them and also because of the doctors doing every little thing they can to charge people as much as possible (like running more tests than are actually necessary).

2. agreed... but why not have a national insurer as most countries do, even canada (my country) half-asses it in that respect, and as such we pay more than other socialized countries even despite paying 40% less than in the US.

3. that one is simple... because it ILLEGAL to discriminate based on gender.

6.they should, unfortunately the alternative medicine industry has been shunned and had decades of pharmsuetical industry propoganda telling (and in most cases convincing) people that natural medicine is a useless waste of time and money. when infact natural medicine tends to work better and have few side effects.

as for your prior comment SOCIETY does a moral obligation to take care of the least of its kind, otherwise were no better than an animal than its its only young for being a runt in the litter... and if thats the case then we really aren't any more civilized than wild animal are.


@Indian.Maid

the question you need to seriosuly think about is A)why they're illegal in the first place (i'll give you a hint its not because they're dangerous by any stretch of the imagination) and B) should they be illegal, and if so under what justification, and remember because you don't like them is not a justification, thats an opinion and a matter of taste.
Posted by Daryl420
21st Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
yeah, sure.
This was tried in the 1950's and 1960's and look at all the folks cured (sarcasm).
Posted by tioedong@...
22nd Aug 2010
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"even at 98-168 hits (over 16000ug or 1mg)"
should be *16mg*

and just so people don't have to actually do the math a lethal overdose would be at roughly 1960-3360 hits of LSD... most people only need 1 or 2 to get high for up to 8 hours.

so in short i dare you to find a safer drug (other than THC), the only thing that makes LSD dangerous is the weak mental state that many (most, in my opinion) people have, and as a result such people have a tendancy to not be able to handle drugs, esspecially psychedelic drugs (at least not in reactional usage), and people that can't handle drugs shouldn't be on them (that applies to all perscription drugs as well as recreational drugs).


@tioedong@...

in fairness most people old enough to have been treated with LSD then would have been dead before the turn of the century; they'd be anywhere from 70-120 years old now... and keep in mind mental illness is on the rise beit by human influnce (diet, lifestyle, truama, toxic exposure to chemicals and certian elements esspecially thing like mercury, aluminum, which casue direct brain damage, often resulting in mental illness) or by a broader more specific understanding of mental illness (such as how autism has now become the more broadly define autism spectrum disorder).

and BTW in clinical usage (other than finding the LD50, or the safe recreational limit) the dosages would almost always be lower than for recreational usage, its not the doctors duty to get you so high you see UFO building the pyramids (apparently a popular vision), but just enough to lift a person out of depression would be quite benificial and MUCH less dangerous than perscription drugs used now like zoloft, prozac, paxil, and cymbalta which tend to always make things worse overall... not to mention they have an extremly low safe dosage range, wheras the safe doage for LSD has been established to be at least 98-168 hits (16000ug; 16mg), which just using the recreational dosage range to the clinical test of extreme recreational usage is still roughly 0.095mg to 16mg; thats alot of wiggle room to find the right dosage, esspecially since the average clinical dose for depression would likely be half an average hit (about 0.00425mg) or less.
Posted by Daryl420
23rd Aug 2010
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RE: Scientists suggest clinical potential for psychedelic drugs
My understanding is that LSD was experimented with as a psychotheraputic agent, but finally after 15 years researchers gave up on that idea. One notes that the discoverer of LSD died not long ago at age 104. It must have made him sad, that LSD had no practical use.
Posted by AlexKovnat
23rd Aug 2010
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So much IGNORANCE about ILLEGAL drugs here!!
Most of you people in these comments are very NAIVE to say the least. Anyhow, here's WHY psychedelics are illegal & alcohol/tobacco are NOT:

"The reason everybody from a Marxist state to a Christian oligarchy to a high-tech industrial democracy can get together and agree that psychedelics are a terrible terrible thing, is because the social effects of psychedelics being taken by large numbers of people is a kind of DECONDITIONING from the cultural myths, whatever they are. It's no knock on any given society, it's just that if people start taking psychedelics, they start QUESTIONING what they've been told about REALITY. And culture is in the business of KEEPING YOU INSIDE a set of predetermined answers to those questions."
~ by the late Terrence McKenna [World famous Author/Lecturer/Scholar on Ecology, Psychedelics, Consciousness, Resource Conservation, Shamanism, Ethno-medicine and founder of the Novelty Theory, a branch of fractal dynamics. More info: http://users.lycaeum.org/~sputnik/mckenna]
Posted by maxtheitpro
24th Aug 2010
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Ooops typo
Terrence McKenna's bio is here:
http://www.lycaeum.org/~sputnik/mckenna/
Posted by maxtheitpro
24th Aug 2010
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