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In pursuit of ADHD treatment, scientists measure attention span of a fly

By | January 26, 2010, 11:26 AM PST

Is the brain of a fly the same as that of a human?

Scientists in Australia have discovered a way to measure the attention span of a fly, which could lead to futher advances in understanding autism and attention-deficit hyperactivity disorder, or ADHD, in humans.

An Australian-German team of scientists at Freie Universität and the Queensland Brain Institute in Brisbane, Australia found genetic mutations that increase or decrease the attention span of a fly.

Using genetic techniques, brain recordings and behavioral testing on the fruit fly, Drosophila melanogaster, Queensland associate Professor Bruno van Swinderen and Freie Universität neuroscientist Björn Brembs found that a fly’s level of distractibility is finely tuned to allow “normal” behavioral responses to a constantly changing environment.

“We now have the two ends of an attention spectrum in our model,” van Swinderen said in a statement. “We have a fly memory mutant that is hard to distract and another fly memory mutant that’s too distractible. They both have the same result — they don’t learn well but for completely different reasons, not unlike human patients afflicted with autism and ADHD.”

The scientists fed the fruit flies methylphenidate — better known as Ritalin — which is used to treat ADHD patients. They found that the drug had a similar effect on the fruit flies, suggesting that there could be similar brain pathways in flies and humans.

“These surprising parallels between insects and humans may point to a general, common functional organization of brains,” Brembs said in a statement.

Their research is published in the Journal of Neuroscience.

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Andrew Nusca

About Andrew Nusca

Andrew Nusca is the editor of SmartPlanet.

Andrew Nusca

Andrew Nusca

Editor

Andrew Nusca is editor of SmartPlanet and an associate editor for ZDNet. Previously, he worked at Money, Men's Vogue and Popular Mechanics magazines. He holds degrees from the Columbia University Graduate School of Journalism and New York University. He based in New York but resides in Philadelphia.

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Andrew Nusca

Andrew Nusca
Andrew Nusca does not hold any investments in the companies he covers.
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RE: In pursuit of ADHD treatment, scientists measure attention span of a fly
Recent research from the University of Hertfordshire in the UK has shown a program called Play Attention (www.playattention.com) can effectively improve attention and behavior.

It allows the students to learn what attention is and how to self-regulate. No fruit flies necessary.

See: http://www.sciencedaily.com/releases/2010/01/100107083904.htm

http://www.additudemag.com/addnews/69/6777.html
Posted by jglennon09
27th Jan 2010
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RE: In pursuit of ADHD treatment, scientists measure attention span of a fly
Mercury is mutagenic; have studies been done to determine whether environmental mercury exposure can cause the ADD/ADHD genetic mutation?
Posted by nhokkanen
27th Jan 2010
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RE: In pursuit of ADHD treatment, scientists measure attention span of a fly
This might be quite the interesting development if ADHD as actually real. However, there's no objective evidence to suggest it's anything but a manufactured condition invented for the purpose of selling treatment for it.
Posted by masonwheeler
27th Jan 2010
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RE: In pursuit of ADHD treatment, scientists measure attention span of a fly
ADHD anything but manufactured. People who can not possibly understand the effects of ADHD are quick to place the cause on something other than an actual medical condition (I'm married to one of those individuals). Without medications, the effects of ADHD are much worse. Adults do not have the hyperactivity associated with ADHD, but the remaining effects are there, real, and can be overwhelming. I have ADD myself and can attest to the severity of the symptoms, and medications help me to function in a society that otherwise could not be tolerated. Current medications alleviate most symptoms, but create other side effects which dictate dosage levels. So, if a fly can lead science to better treatments, or a better understanding of the core issues, then people like myself can remain hopeful.
Posted by marko...polo
29th Jan 2010
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