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Scientists discover how a key enzyme heals sun-damaged DNA

By | July 27, 2010, 10:30 AM PDT

Imaging lathering yourself with subatomic sunscreen before you venture out into the sun. The sunscreen could do more than just protect your skin from harmful ultraviolet light — it could fix your sun-damaged skin instantly.

However, the pro-active skin care products are a bit futuristic. But the idea of using products that can rapidly repair DNA might one day be possible thanks to a laboratory discovery made by Ohio State University scientists.

The researchers witnessed for the first time how the enzyme photolyase repairs sun-damaged DNA — and it does so in a few billionths of a second.

The thing is, this enzyme is found in plants and animals (except mammals).

Bacteria has this protection, but we don’t. So when our skin is exposed to the sun, the ultraviolet light makes chemical bonds form in the wrong places along the DNA.

Sun-damaged skin is more than a superficial problem.

What happens on vacation, doesn’t necessarily stay there. Our choices we make about our exposure to the sun is a major health issue.

As you probably already know, chronic sun damage causes DNA mutations that can lead to skin cancer and other diseases.

The experiments didn’t take place on a beach or anywhere like that.

In a lab at Ohio State, the physicist and chemist Dongping Zhong synthesized DNA and gave it an artificial dose of sunshine by applying ultraviolet light. After the DNA appeared to have the same hallmarks of sun damaged skin, Zhong added the enzyme to the mix.

That’s when the scientists stalked the enzyme’s every atomic move. Zhong used ultrafast light pulses to take a series of pictures to see how the photolyase worked on the DNA. The enzyme basically gets rid of the wrong chemical bonds that formed during sun exposure and quickly makes the bonds revert back into how they were before during the sun damaged it.

But it doesn’t stop there. The photolyase then gets its photon and electron back because original bond doesn’t need it anymore. This way, the enzyme can continue to repair other damaged DNA.

“It sounds simple, but those two atomic particles actually initiated a very complex series of chemical reactions,” Zhong said in a statement. “People have been working on this for years, but now that we’ve seen it, I don’t think anyone could have guessed exactly what was happening,”

While we have some other enzymes that can heal damaged DNA, it doesn’t quite work as well as the photolyase.

In the future, I wouldn’t be surprised to see the shelves at a local drugstore full of skin care products capable of healing our sun-damaged DNA skin, made with the special ingredients: two subatomic particles.

Until then, use regular sunscreen and umbrella chairs for added protection.

If you’re thinking of emailing Zhong to ask him which lamp to buy, don’t. Someone already asked him that. Humans don’t have the enzyme, he explained to the curious email correspondent. Now if you have fish, that’s another story. In that case, use visible blue light in the fish tank to undo any previous UV damage.

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Boonsri Dickinson

About Boonsri Dickinson

Boonsri Dickinson was a contributing editor for SmartPlanet from 2010 to 2012.

Boonsri Dickinson

Boonsri Dickinson

Contributing Editor, Science

Boonsri Dickinson is a freelance journalist based in San Francisco. She has written for Discover, The Huffington Post, Forbes, Nature Biotech, Technewsdaily.com, Techstartups.com and AOL. She's currently a reporter for Business Insider. She holds degrees from the University of Florida and the University of Colorado at Boulder.

Follow her on Twitter.

Boonsri Dickinson

Boonsri Dickinson

In the unlikely event that Boonsri has a professional or financial relationship with a company she writes about, it will be prominently disclosed.

She writes for SmartPlanet and is not an employee of CBS.

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RE: Scientists discover how a key enzyme heals sun-damaged DNA
Very nice!! Muito Legal!! Mucho bien!!!!
Posted by danielat
28th Jul 2010
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RE: Scientists discover how a key enzyme heals sun-damaged DNA
"...skin care products ... made with the special ingredients: two subatomic particles." is pretty misleading. The ingredient is the enzyme, which provides the particles as part of a chemical reaction - pretty much like any chem reaction.

"Subatomic sunscreen" makes a catchy headline, but I'm disappointed SciAm was pretty inacurate in that too.

As a Science blogger, I'd hope that accuracy would win out over catchiness...
Posted by rand.wrobel@...
28th Jul 2010
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RE: Scientists discover how a key enzyme heals sun-damaged DNA
I have a patented process that already repairs sun damage and
can cure melanoma through a simple process with water. It also
will cure kidney, liver, prostrate diseases, along with melanoma,
and man other remedies. Doctors don't particularly care for it
because they don't and won't take the time to understand it (it
does concern nuclear physics like above) and it does
permanently cure people and is simple, so it takes away from
their income. It seems like magic to them because it is too far
advanced for them. They keep calling it a miracle. At least I now
have 13 miracles.
Posted by stevensedlmayr
28th Jul 2010
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