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A genetic test for dieters

By | March 3, 2010, 12:43 PM PST

Maybe the hit TV show, The Biggest Loser, should add a genetic component to help contestants lose weight.

Interleukin Genetics might have a simple answer to the low-carb versus low-fat dilemma. The company’s DNA test checks your saliva for genes that influence fat and carbohydrate metabolism. While there are hundreds of genes linked to obesity, the Interleukin Genetics tests for 3 genes: fatty acid binding protein 2, peroxisome proliferators activated receptor gamma, and beta 2 adrenergic receptor.

Working with Interleukin Genetics, Standford University professors conducted a study involving 138 overweight women. The women with genes for a low-carb diet lost more weight than women without those genes. Two and a half times more weight, in fact. And the women who had a genetic predisposition to the low-fat diet, also lost more weight than those without it.

The Wall Street Journal reports:

“Knowing your genotype for low carb or low fat diets could help you increase your weight-loss success,” said Christopher Gardner, an associate professor of medicine at Stanford and senior author of the study.

Of course, more studies need to be done to determine if the test is actually useful. Also, the scientists will have to study men and ethnic groups, as WSJ’s Ron Winslow points out.

Regardless of your genes, both the low-fat and low-carb diets are good for your heart. However, if you’re looking to maintain weight loss long term, scientists say a low-fat diet is best.

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Boonsri Dickinson

About Boonsri Dickinson

Boonsri Dickinson was a contributing editor for SmartPlanet from 2010 to 2012.

Boonsri Dickinson

Boonsri Dickinson

Contributing Editor, Science

Boonsri Dickinson is a freelance journalist based in San Francisco. She has written for Discover, The Huffington Post, Forbes, Nature Biotech, Technewsdaily.com, Techstartups.com and AOL. She's currently a reporter for Business Insider. She holds degrees from the University of Florida and the University of Colorado at Boulder.

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Boonsri Dickinson

Boonsri Dickinson

In the unlikely event that Boonsri has a professional or financial relationship with a company she writes about, it will be prominently disclosed.

She writes for SmartPlanet and is not an employee of CBS.

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RE: A genetic test for dieters
The satement:"scientists say a low fat diet ..."
Low fat has other consequences. Fat slows down metabolism of carbohydrates thus being beneficial for diabetes patients. What all these general statements fail to take into consideration is the individual make-ups and metabolisms. What is good for one person is bad for another. My wife who has type 2 diabetes does very badly on high carb diets. She has maintained a modified Atkinson diet (basically high fat/low carb) for 30 to 40 years. Her diabetes onset ocurred some 15 years later than predicted, she was over 70, she believes thanks to her diet. So please in serious articles try to avoid those generalities, or at least qualify them.
Posted by fritsau
4th Mar 2010
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