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Will your genetic source code be open or closed?

By | July 13, 2009, 11:50 AM PDT

The use of genetics in finding cures to diseases, now called genomics, may be the key to both your future health and economic growth.

Starting with the sequencing of a virus DNA by Fred Sanger in the 1970s, and extending to the sequencing of the entire human genome in 2001, scientists have been consumed with the task of decoding your genes, the genomes of disease, and manipulating genes to make new medicine.

Most of the work has been done in what computer scientists would call “closed source,” in that genomes are subject to patent rights.

But there have long been efforts to carve out a place for open source in the effort, starting with the donation of the Human Genome Project’s work in the government’s GenBank system. Versions of the H1N1 flu virus are also being submitted to GenBank.

The open source advocates at O’Reilly point out that open source software has also been part of that mix, personifying that effort in David Dooling (above), assistant director for infomatics at the Genome Center in St. Louis.  His work uses a lot of open source software.

But there is a larger question, one I want readers to weigh in on.

Where will the most progress come from? Does the path to cure lead through the private ownership of genetic codes, or will we make more progress is genes are part of the open source world?

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Dana Blankenhorn

About Dana Blankenhorn

Dana Blankenhorn was a contributing editor for SmartPlanet from 2009 to 2010.

Dana Blankenhorn

Dana Blankenhorn

Contributing Editor, Healthcare

Dana Blankenhorn has written for the Chicago Tribune, Advertising Age's "NetMarketing" supplement and founded the Interactive Age Daily for CMP Media. He holds degrees from Rice and Northwestern universities. He is based in Atlanta.

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Dana Blankenhorn

Dana Blankenhorn

Dana Blankenhorn has been a technology reporter since 1982, a business reporter since 1978, and a writer for as long as he can remember. His Schwab IRA has a few tech stocks in it, most notably some Intel and Applied Materials bought over 10 years ago. But the vast majority of his tiny fortune (emphasis on the word tiny) is invested in mutual funds. He presently writes for no one else but ZDNet, SmartPlanet and himself. But if you've got an opportunity let him know. If he takes the gig he"ll first add it to this disclosure page.

He writes for SmartPlanet and is not an employee of CBS.

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0 Votes
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awake
Open Source will probably lead to better results for this kind of project, plus one does not have to worry about moral issues that corporations tend to have (greed is inherent in capitalism unfortunately - it is what it is).
Posted by awake!
14th Jul 2009
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RE: Will your genetic source code be open or closed?
I also opt for Open Source for faster and more transparent progress. Big
projects of this caliber call for concerted efforts in order to expose the full
gamut of capabilities. This can best be achieved with Open Source
research.
Posted by Pastrami
14th Jul 2009
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No
A person's body belongs to them, their genetic code belongs to the entire human race, not some company that decodes it.

A company that produces a unique genetic organism, such a a mouse with special genes, can patent that particularly coded mouse lineage. The same with bacteria, plants, viruses, fungi, etc.

The grey area would be if they were to make an intelligent, self-aware species capable of intelligent human language use. If it were capable of being educated to the 3rd grade or higher, and function solo in society, it could arguably be considered an independant person. In tat case the company would not even retain in loco parentis rights over that person; although they would retain rights to the genetic code. Make enough for them to reproduce on their own and you have a new, intelligent species and then their genetic code belongs to them, not the company.
Posted by Dr_Zinj
15th Jul 2009
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RE: Will your genetic source code be open or closed?
Probably from the closed system, based on the big money that pharmaceutical companies will provide to have an additional edge on creating customs made medicines
Posted by eyewalker
15th Jul 2009
0 Votes
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RE: Will your genetic source code be open or closed?
Open, the U.S. and civil liberty at now at odds at every turn. Choice is not an option. Has nothing to do whether Open is better or not.
Posted by sk.dunnage@...
15th Jul 2009
0 Votes
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RE: Will your genetic source code be open or closed?
Closed source will target a small subset of problems where a profit is
likely. But, real progress - the big steps forward - will require large team
cooperations across specialty areas. That will only be achievable if the
teams can all use the outcomes as they wish - and that will only be
possible under the open source model
Posted by Charlie2811@...
15th Jul 2009
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RE: Will your genetic source code be open or closed?
In fact, computer scientists would not refer to DNA as "open source" because DNA is already compiled. Instead, what you are referring to is the right to "reverse engineer" DNA.

For example, I have a CD containing Microsoft XP. This CD is analogous to a CD containing DNA. We can run the code to make the system work. But giving away the CDs does not provide any of the benefits of "open source". Open source is powerful because it is easy to see how the code works. With DNA, we need much more than the DNA itself, we also need information about the people who donate the DNA, such as their health problems and other phenotype expression of that DNA.

I believe that giving freedom to reuse DNA is most similar to the term "open content", not "open source".
Posted by ioot@...
16th Jul 2009
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RE: Will your genetic source code be open or closed?
I will cry on the day that a company sues somebody because their DNA is in violation of a patent.
Posted by ioot@...
16th Jul 2009
0 Votes
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RE: Will your genetic source code be open or closed?
It's probably going to be a mixture. Right now it takes a tremendous amount of talent and money to figure out what DNA is doing. That can best be done by commercial firms with a profit motive. But once DNA is more fully understood and the equipment becomes much cheaper, it probably can be done in the open source arena.

There's a historical analogy with the computer industry. The first couple of decades ('50s and '60s) computing resources took many times the annual income of private individuals. Open source would have had little practical value, though I guess some code sharing was being done among user groups. But once computing became dirt cheap, open source truly became possible and a major force in the industry.

However, the potential dangers of DNA manipulation may force governments to keep it tightly controlled, with strict licensing and inspection protocols. In that case, open source DNA will probably never flourish.
Posted by zackers
16th Jul 2009
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RE: Will your genetic source code be open or closed?
Open or closed? Quite possibly irrelevant: as more and more is learned about the human genome, researchers are finding that genetic sequences cannot possibly account for all the maladies that seem inexplicably to arise and affect the human condition. They are discovering that other (seemingly external) factors may be at work altering genetic sequences, and have labeled the study of these factors "epigenomics" or epigenetics (depending on whether the subject is the whole genome or a specific genetic sequence). See http://hmg.oxfordjournals.org/cgi/content/full/15/suppl_1/R95
Posted by psquare11
16th Jul 2009
0 Votes
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wrong question
Both sides could lead to big breakthroughs - the problem with closed source is that
when something IS found then it is invariably withheld from people who need it in order
to squeeze out every dollar the owners of the patent can get out of it.
Posted by Hobyx
17th Jul 2009
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RE: Will your genetic source code be open or closed?

I have been noting for some time that there should be no right to patent DNA or any DNA segment. DNA is unique to the person who "owns" it.
Patenting tests based on discovered DNA segments is another story in that a Patent represents "previously undiscovered knowledge" and an application based on that knowledge.
It is misguided to thwart the innovation that comes from discovery and the Patenting process. However, attempting to claim the particular DNA segment that gives rise to a test for disease or other precursors runs afoul of the prerequisite "obviousness" provision, in that a manifestation that is easily and readily observable by anyone, without further modification, is not patentable.
How about my heart? Can I patent my heart? I own it, it is unique to me, and shouldn't be "owned by anyone else. If you believe a heart, or a liver, or a brain is by definition an extension of the DNA that created it, then no logic or application of law gives right to grant ownership to anyone else, except perhaps by Contract between the parties; a contract whose provisions must as legal as other contracts.
Posted by SocratesRedux
23rd Jul 2009
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Posted by marquesthomas
24th Jul
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