By Janet Fang
Posting in Cancer
No more needles? Now, daily injections of insulin or cancer drugs could be replaced by uPill, which uses ultrasound waves to heat up gut tissue, accelerating the drug's absorption.
For many people with diabetes or cancer, daily injections are a painful fact of life. Substances like insulin and protein-based cancer drugs don’t penetrate tissue quickly enough to be effective when taken orally.
But ultrasound has been used for years to accelerate the transfer of drugs through the skin, increasing drug absorption by a factor of 10. It works by heating up the molecules inside skin tissue.
Now that same method takes on a pill form. The uPill uses ultrasound to increase the absorption rate of drugs through tissue in the gastrointestinal tract, according to MIT’s Daniel Anderson, part of the team developing the device.
- The drug is applied as a coating to the uPill.
- After it’s swallowed, the device sends ultrasound waves through the patient’s gut tissue, aiding absorption through the stomach.
- Then the device should pass through the digestive system (coming out the way a tiny camera would).
"We are developing the smallest ultrasound system in the world,” says George Lewis of ZetrOZ, which has previously developed an ultrasound patch to deliver drugs through the skin.
Each pill would cost between $20 and $30 and could hit the market in the next couple years. Animal tests are now being carried out to see if the device can pass through the digestive system safely.
The device was presented at the IdeaStream conference at MIT last month.
[Via New Scientist]
Jun 25, 2012
I have diabetes and take 2 types of insulin 3 times per day at different doseages. That would mean I would need 6 upills per day. 1. 6 x $20 = $120 per day. That is double my insulin cost, for a 2 month supply. 2. How is the dosage applied to the upill ? There is no standard dosage as you adjust the dosage for your blood reading and the meal you are about to have. Sorry, don't see how this will help anyone with diabetes.