By Janet Fang
Posting in Cancer
Researchers have come up with a new drug that targets fat tissue by destroying its blood supply. Monkeys have lost 38% of their body fat and are at lower risk for type 2 diabetes.
Researchers are working on a new drug that targets fat tissue by destroying its blood supply. So far, it works in monkeys who had became spontaneously obese all by themselves.
Right now, there are only 2 types of weight loss drugs that are approved by the US Food and Drug Administration: an appetite suppressant and a fat inhibitor. But they sort of have toxic side effects.
Previous mouse studies have shown that targeting the blood vessels of fat tissue (or white adipose) reduced a third of their body weight. White adipose just under our skin stores fat and provides us with insulation.
"Development of this compound for human use would provide a non-surgical way to actually reduce accumulated white fat, in contrast to current weight-loss drugs that attempt to control appetite or prevent absorption of dietary fat," says study author Renata Pasqualini of the University of Texas M. D. Anderson Cancer Center.
The drug selectively binds to a protein on the surface of fat-supporting blood vessels and kills those cells within blood vessels of adipose tissue. (It’s like starving a tumor by cutting off the blood vessels that supply it.) Without blood supply, fat cells are reabsorbed and metabolized.
In 10 rhesus monkeys, one month of treatment resulted in:
- Rapid weight loss. Up to 15% of their body weight.
- Reduced body fat. MRIs scans show that the treated monkeys shed 38.7% of body fat on average. Pictured, monkey before and after (red is fat).
- Slimmer abdominal circumference (waistline). Up to 14%.
- Improved insulin resistance, which makes them at lower risk for type 2 diabetes and cardiovascular disease.
The monkeys remained bright and alert throughout, interacting with caretakers and demonstrating no signs of nausea or food avoidance. Though, side effects included increased amounts of urine and slight dehydration, both symptoms of mild kidney failure.
The study was published in Science Translational Medicine last week.
Nov 15, 2011
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If these drugs are going to be safe for humans, why not test them on the families of the drug company. Testing animals because fat lazy humans need help with their fat isn't ethical to me. When I have gained weight, my intake was greater than my output.
Fat monkeys indeed! If Americans hadn't become so obese this kind of research wouldn't exist. When will people realize that obesity is a dis-ease?
They've found a drug that does what eating right can do. Pretty soon we won't have to eat anything but pills. THX 1138 here we come...
... this is kind of scary for a number of reasons. I mean, what would the world be like without fat monkeys? (just kidding).
... caused by too many artificial ingredients in our food as preservatives, sweeteners and flavor enhancers. One of the worst of these artificial ingredients is High Fructose Corn Syrup; obesity among Americans really started just about the time "New Coke" and other HFCS-sweetened beverages and foods hit the market.