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Low cholesterol is really good for you

By | November 4, 2009, 9:56 AM PST

A new National Cancer Institute study, examining the lives and deaths of 30,000 Swedish smokers, has concluded that low total cholesterol, which was thought to be a risk factor for future cancer, may have been a sign of cancer itself.

(Ah, Homer. Is there nothing you can’t make funny?)

The low cholesterol-cancer link has long confused scientists, but Demetrius Albanes and his team found that the supposed increased risk of cancer disappeared after nine years, meaning “lower total cholesterol may be caused by undiagnosed cancer.”

The same study showed a link between high levels of HDL or “good” cholesterol and a lower risk of developing prostate cancer. The research will go into the journal Cancer Epidemiology, Biomarkers and Prevention.

A second study, conducted at Johns Hopkins, found a total cholesterol level below 200 reduced the chances of getting a highly-aggressive form of prostate cancer by 59%. Elizabeth Platz and her team examined the cases of 5,586 men given placebos in a previous prostate cancer prevention trial, of whom 1,281 had gotten the cancer.

The bottom line here is more good news for statins like simvastatin, which were originally developed against heart disease. Keeping total cholesterol low reduces the chance of cancer. So does keeping good cholesterol high. If yours suddenly drops to a very low level see your doctor.

A personal note. My own cholesterol was over 300 before I went on statins 10 years ago, and now sits around 150. Due to a family history of very low HDL cholesterol levels, I was also put on timed-release niacin (available as a dietary supplement at most drug stores, as well as in the drug Niaspan) and now those numbers are tickety-boo.

Hope your numbers are happy, too.

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Dana Blankenhorn

About Dana Blankenhorn

Dana Blankenhorn was a contributing editor for SmartPlanet from 2009 to 2010.

Dana Blankenhorn

Dana Blankenhorn

Contributing Editor, Healthcare

Dana Blankenhorn has written for the Chicago Tribune, Advertising Age's "NetMarketing" supplement and founded the Interactive Age Daily for CMP Media. He holds degrees from Rice and Northwestern universities. He is based in Atlanta.

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Dana Blankenhorn

Dana Blankenhorn

Dana Blankenhorn has been a technology reporter since 1982, a business reporter since 1978, and a writer for as long as he can remember. His Schwab IRA has a few tech stocks in it, most notably some Intel and Applied Materials bought over 10 years ago. But the vast majority of his tiny fortune (emphasis on the word tiny) is invested in mutual funds. He presently writes for no one else but ZDNet, SmartPlanet and himself. But if you've got an opportunity let him know. If he takes the gig he"ll first add it to this disclosure page.

He writes for SmartPlanet and is not an employee of CBS.

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RE: Low cholesterol is really good for you
You have incorrectly assumed that cholesterol lower by drugs also lowers the risk of diseases associated with high cholesterol.
Posted by edcoyle
5th Nov 2009
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RE: Low cholesterol is really good for you
Are you doing any cardiovascular exercise 3 times a week? This too will increase the good HDL cholesterol. Diet and exercise are as important a consideration as the genes we were dealt. If you like me you carry your weight mostly in the belly. Another nice genetic gift and a marker for Metabolic Syndrome, amongst others (elevated triglycerides and blood pressure). Dr. McDougall (drmcdougall.com) has been turning cholesterol number around with just diet. Vegan is a tough diet for those who are not OCD, but I might consider it as the next alternative. A not quite vegetarian diet and exercise along with 1 gram of time release niacin at bed time has my LDL down to 150 from up over 240. I hope it continues to improve. Keep up the good fight.
PharmD Reader
Posted by kfricker
6th Nov 2009
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Edcoyle
Studies show that lowering cholesterol through statin drugs, when diet and exercise don't work, has enormous health benefits. Period.

There are people who argue otherwise, but the bulk of the scientific evidence goes the other way.
Posted by DanaBlankenhorn
11th Nov 2009
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Kfricker
I exercise 6 times a week. I take niacin. My high cholesterol is genetic in origin. On my first test in 2000 it was 373. I was not overweight, I do not smoke. It's now about 150.

I appreciate what diet and exercise can do. For some people they provide an enormous benefit on the cholesterol front. Niacin can not only reduce total cholesterol, but it's really good at raising the leverl of good (HDL) cholesterol. My ratio is now under 2-1, which is really really good.

Despite all these gains my triglycerides remain over 150.

My guess is that my northern European ancestors, thousands of years ago, dealt with widespread famine so that only those whose bodies stored all the fat they could survived. And passed on their genes to me.

But I live in a land of plenty. What was good for them is bad for me.
Posted by DanaBlankenhorn
11th Nov 2009
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