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An artificial pancreas just a few years away

By | April 15, 2010, 10:53 AM PDT

It’s called an artificial pancreas. It’s basically a collection of sensors, a pump, and a tiny computer no bigger than today’s insulin pumps.

The idea is that the sensors would continually test blood sugar, the computer would decide when insulin or glucagon is needed, and the pump would deliver the goods automatically.

The software is the key to the whole thing. And now the software works.

Steven Russell and his team at Harvard report they have tested their algorithm on 11 patients, collecting data and delivering medicine manually and running the calculations on a laptop.

Their description of the system in Science Translational Medicine triggered a response from MIT in the same issue, approving of the idea.

The goal is to have a device ready in 2015 for Type I diabetics, people who currently must give themselves daily injections of insulin based on regular checks of their blood sugar levels. The proposed Harvard device would include manual overrides.

The hope is that the automated testing, and inclusion of glucagon, will provide finer control over blood sugar levels, minimizing side-effects of the disease, allowing for both a more normal lifestyle and completely normal lifespan.

Amy Tenderich, community manager at Diabetic Connect and manager of her own site, Diabetes Mine, wrote recently that “usability wars” in diabetes pumps are just starting, with Roche’s purchase of Medingo, makers of the Solo Patch pump. A completely automated system would turn this industry on its ear.

The Juvenile Diabetes Research Foundation, chaired by Mary Tyler Moore, has been pushing the artificial pancreas idea for years and its research director recently  told HealthDay News it is jazzed about the whole thing, believing the coming device will “transform the management of diabetes.” (The illustration is from the JDRF.)

The group recently announced it was working with Johnson & Johnson to bring artificial pancreas technology to market. The group has yet to produce a news release on the Harvard research. Harvard is not part of the JDRF’s research consortium.

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Dana Blankenhorn

About Dana Blankenhorn

Dana Blankenhorn was a contributing editor for SmartPlanet from 2009 to 2010.

Dana Blankenhorn

Dana Blankenhorn

Contributing Editor, Healthcare

Dana Blankenhorn has written for the Chicago Tribune, Advertising Age's "NetMarketing" supplement and founded the Interactive Age Daily for CMP Media. He holds degrees from Rice and Northwestern universities. He is based in Atlanta.

Follow him on Twitter.

Dana Blankenhorn

Dana Blankenhorn

Dana Blankenhorn has been a technology reporter since 1982, a business reporter since 1978, and a writer for as long as he can remember. His Schwab IRA has a few tech stocks in it, most notably some Intel and Applied Materials bought over 10 years ago. But the vast majority of his tiny fortune (emphasis on the word tiny) is invested in mutual funds. He presently writes for no one else but ZDNet, SmartPlanet and himself. But if you've got an opportunity let him know. If he takes the gig he"ll first add it to this disclosure page.

He writes for SmartPlanet and is not an employee of CBS.

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RE: An artificial pancreas just a few years away
Hmmm, an artificial pancreas, it sounds like a load of hype. A pancreas delivers more than insulin. Can this machine replace a pancreas? On the other hand, this does look like a smart insulin delivery system.
Posted by bd1235
16th Apr 2010
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RE: An artificial pancreas just a few years away
You're right in that the pancreas delivers much more than
insulin. However, patient's with Type 1 diabetes don't have a
completely dysfunctional pancreas. They have destruction of the
beta cells which secrete insulin and some other regulatory
proteins. The other pancreatic enzymes necessary for digestion
of food are still there. Patients with Type 1 DM have dysfunction
in glucose control, and the two major hormones involved in
maintaining blood glucose levels are insulin and glucagon. Read
the article a little closer and you'll see that the pump they are
currently testing secretes glucagon in addition to insulin. Using
both of these hormones should allow for a much finer level of
control of the patient's glucose levels with less risk of
hypoglycemia (since if the patient begins going low presumably
the sensor will detect this and pump some glucagon into the
patient which will stimulate the liver to release some glucose
from the glycogen stores). This won't completely mimic the
normal beta cells that have been lost since there are some other
hormones (like amlyn) that are missing in patients with type 1
DM, but this seems like a much more elegant solution than the
current insulin pumps, and certainly much better than having to
inject oneself 2-4 times a day.
Posted by Pharmer John
16th Apr 2010
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Your so third and 10th removed .. do you even care?
Why did you even type this article.. a copy of someone else's work?
You haven't proved that you've rethought healthcare .. you're copying
old lies. Hey if you want to suck and be a hate because your ignorant
fine .. I'll tell everyone.
Posted by oneal.j
16th Apr 2010
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RE: An artificial pancreas just a few years away
A definite move in the right direction to help people that are diabetic.

Ben Koshkin
Posted by landdev
17th Apr 2010
0 Votes
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It would be a very nice invention
However, past experiences suggest that it will probably still take
decades before we get a properly functioning betacell replacement
system. By all means, lets hope the researchers keep up the good work,
but don't be too disappointetd if they don't succeed.

(What's up with oneal.j? That person seems so angry.)
Posted by Dukhalion
18th Apr 2010
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RE: An artificial pancreas just a few years away
This sounds great, But what would be almost as good, maybe
better, is just a continuos read out of blood sugars. I don't mind
injecting. I just need to know my blood sugar level ALL THE
TIME. If I had a wristwatch that showed me my blood sugar
level ar any time, I wouldn't need a pump or a computer. I have
a brain and it works pretty good. Now I could accomplish the
same ting by testing myself 2000 times a day, but as you might
guess it would be a little inconvenient. Since your device
includes a constant readout device, send it to me. That's ALL I
need.
Jeff
Posted by Jeff Nixon
25th May 2010
0 Votes
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RE: An artificial pancreas just a few years away
This was an exciting headline, pancreatic cancer being almost
invariably deadly. But this is a far cry from an artificial pancreas,
and I find it hard to believe its developers are calling it that.
Sounds as though it might better be called artificial islets of
Langerhans. A more accurate headline really is called for.
Posted by John Mayer
9th Aug 2010
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Re - etc, etc.
I have Diabetes Mellitus (Type 1) and have done since 2002. I think this invention would do absolute wonders, the title of this article shouldn't have said artifical pancreas obviously, but either way it's a way for us type 1 diabetics to be able to have the equivalent of an artifical pancreas..
I hope so badly this becomes a real deal, that is available to everyone. It may not seem like a hardship but living with the constant threat of hyperglycemia and hypoglycemia is mentally exhausting.
Go harvard!
Posted by Tracyffs
4th Aug
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