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A cancer cure health reform may delay

By | March 22, 2010, 9:15 AM PDT

There may be a big breakthrough in cancer therapy coming.

A study published in Nature, from a team headed by CalTech chemical engineering professor Mark Davis (right), proves a method for RNA Interference, using tiny bits of RNA injected into the blood, which interfered with the reproduction of tumor cells.

There is tremendous excitement over “game-changing” therapies for cancer, Parkinson’s, and chronic pain.

As always there is also a compelling back story.

Davis began his work after watching his wife nearly die from breast cancer treatments. The work he has just done on humans replicates research that won Andrew Fire and Craig Mello the 2006 Nobel Prize for Medicine.

The work was done by a CalTech corporate spin-off, Calando Pharmaceuticals, owned by Arrowhead Research, and shares in Arrowhead jumped on the news.

But the path from discovery to market gets longer under health reform.

As The Scientist notes, the study did not prove the therapy was controlling the cancer. Killing some cancer cells with a novel treatment does not effect a cure. You have to get them all.

Not only that but in most countries, and the U.S. under health reform will gradually become like most countries, you will not only have to prove a therapy works, but that it’s cost-effective compared to other treatments., before it goes into general use.

This is a big hurdle many drugs and devices find hard to jump in Europe. It’s why the U.S. is the leader in developing new therapies.

Failing to prove comparative effectiveness, new treatments can be used only on patients willing to pay cash. There will be sick rich people looking to this therapy when it’s ready, in about five years. But don’t expect insurance or Medicare to cover it until it proves it’s cost effective.

Experiments are great, and sometimes being a guinea pig pays off. But new treatments will go first to those who can afford the expense and risk of failure, only later to the rest of us.

That’s just the way it has to be. The days of bankrupting the many in the name of curing a few are over.

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Dana Blankenhorn

About Dana Blankenhorn

Dana Blankenhorn was a contributing editor for SmartPlanet from 2009 to 2010.

Dana Blankenhorn

Dana Blankenhorn

Contributing Editor

Dana Blankenhorn has written for the Chicago Tribune, Advertising Age's "NetMarketing" supplement and founded the Interactive Age Daily for CMP Media. He holds degrees from Rice and Northwestern universities. He is based in Atlanta.

Follow him on Twitter.

Dana Blankenhorn

Dana Blankenhorn

Dana Blankenhorn has been a technology reporter since 1982, a business reporter since 1978, and a writer for as long as he can remember. His Schwab IRA has a few tech stocks in it, most notably some Intel and Applied Materials bought over 10 years ago. But the vast majority of his tiny fortune (emphasis on the word tiny) is invested in mutual funds. He presently writes for no one else but ZDNet, SmartPlanet and himself. But if you've got an opportunity let him know. If he takes the gig he"ll first add it to this disclosure page.

He writes for SmartPlanet and is not an employee of CBS.

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Waiting for the rich to serve as guinea pigs?
It was a good article until the very end. I don't follow your logic at all. Apparently you feel we have to give up development of new therapies as a result of health care reform, which is ridiculous.

One thing about the rich, there are relatively few of them. That means it will take years to develop the statistics necessary to prove a treatment. Some rarer diseases may never have enough trials.

And you can't prove a treatment is cost-effective until it starts to see widespread use. If, for example, we based electric car viability on the current price of lithium ion batteries versus the current cost of gasoline engines, then electric cars would never become available. Does anybody expect lithium ion batteries to become cheaper because of all the Teslas being sold? So according to your logic, we better give up on replacing the gas car. After all, it's cost-effective and works very well.

You may be a big proponent of Obamacare. Fine. But to meekly accept that it also means a radical slowing down of new treatments (already a glacial process by its very nature) just doesn't make sense. Over the coming decades, the way to make health care truly cheap and routine is through greater research and development. All the cost savings in Obamacare are just bandages that will eventually succumb to inflation and greatly increased demand.

You talk about "bankrupting the many in the name of curing a few". And yet it has been the few (mostly the US) that have provided the treatments that saved the many all over the world. By killing new R&D in the US health care reform threatens the future health of the rest of the world. Maybe instead of giving up we should be looking for ways to encourage R&D. It seems to me this is what any compassionate person would do instead of giving up.
Posted by zackers
23rd Mar 2010
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Immoral triad of a simpleton
One day when this simpleton is ill and depraved, the incoming healthcare system he is so glad to support today will tell him to go off and die in a corner since it would be to costly to justify curing him (R&D not yet compete or enough invested) and then he will understand the morality of his words.

It is one thing to stir up debate it is another to use such immoral, insensitive and illogical words. This seems to be a pattern with Dana. To SmatPlant (CBS) human resource department, you could not find any better than Dana? There are so many people looking for work.
Posted by mario@...
24th Mar 2010
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zackers
I support the health care reform bill, true. But I'm realistic. One reason the US leads in areas like drugs and medical devices is because doctors don't have to worry about cost effectiveness in prescribing them. As the U.S. becomes more like the rest of the world -- as our percentage of GDP devoted to health care declines -- these devices and drugs have a smaller potential market.
Posted by DanaBlankenhorn
24th Mar 2010
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mario@..
People die. You can't prevent it. You can only delay it.

The question is how far do you delay it, and what you will pay to delay it, and for whom?

If you don't like my stuff, don't read it. Read only people you agree with if you wish. But I'm going to continue challenging assumptions -- including my own -- so long as the editors let me.

As Alan Alda (as Hawkeye) said to a patient who'd turned against him on M*A*S*H, "have a long productive hate." (Don't know if it was Ken Levine or David Isaacs who wrote that -- they shared credit.)
Posted by DanaBlankenhorn
24th Mar 2010
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Integrity is more than a word is it a principle expressed through action
Yes we will all die, however the question is not ?how far do you delay it, and what you will pay to delay it, and for whom?? Rather the first question is which type of society makes that journey to the inevitable the most satisfying. The second then becomes how do be build it and third how is it maintained. Then in that case the issue is not to what degree the community maintains certain services and who has access but rather there is an equality base all members are ascribed to and thus it is in all their mutual common interest to create the best system possible. That is the principle behind Canada?s Health Care System. Although not perfect it is meant to serve the needs of the human national and not the inhuman multinational cooperation as the bill push by Obama. Further it is immoral and offensive to say ?Experiments are great, and sometimes being a guinea pig pays off. But new treatments will go first to those who can afford the expense and risk of failure, only later to the rest of us.? Was that the position of your fictitious character played by Alan Alda? When it comes to health, life and death suggesting someone should be a ?guinea pig? is quite insensitive and offensive. Should that that be you? You want to be my guinea pig? Again a health care system predicated upon all people treated as equal regardless of wealth does not impose such immoral standards. We all have access to the best the system has to offer and if we choose, then even the most radical of treatments.

Dana if you describe yourself as a journalist then I have as much right to critique you as you have to write. Thus if I read something which is inaccurate, immoral (from my perspective) or wrong I may choose to comment on it for various reasons such as to correct, inform or to express my point of view. What sense is there to read what I already know? Further I was taught that a journalist must have integrity defined by the professional standard of reporting not filtering information by expressing yours? or cooperates personal point of view. You say that ?I'm going to continue challenging assumptions -- including my own...? However I have yet to read any articles on Climate Change al a Global Warming which presents more than one point of view even though there are many scientists who through their research have reached a different hypothesis, theory or conclusion. This has been made aware to you by myself and others who have blogged responses and links to that research for you to write articles on. Thus if it were true that you challenged assumptions such as anthropomorphic global warming or even the notion of global warming then please provide link to those article(s) you have written for me to read. Even with this health care reform bill of Obama you simply write articles supporting it without any critiques or opposing perspectives. Why not write an article cliquing the current and proposed U.S. health care system and how it compares to other countries such as Canada? Why not challenge the assumptions?

Perhaps I forgot to read the fine print which said that you are not practicing journalism rather propaganda and censorship or this is what journalism has come be defined in the U.S. That is ?let?s not question just present what we are told or what WE know is correct and to hell with opposite or contradictory information, they are all wrong anyways.?
The middle class in the U.S. has been experiencing the log good buy, in order for that to occur all branches of government and the media must negate their fiduciary responsibilities to the nationals they serve.

To quote Jack Parsons from the book "Freedom Is a Two-edged Sword."
Censorship in any form is the opening wedge for fascism, since it places arbitrary and unwarranted power in the hands of individuals.
Posted by mario@...
25th Mar 2010
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mario@.
What we demand of journalists is not lack of bias. We ask them to be
upfront about their biases and fair to critics.

Have at me as much as you like. But calling lies truth, as you wish
me to do with global warming denial, is not fairness.

It's buying political spin in the face of hard science. The last
decade was the warmest on record, and the evidence of climate change
is all around us.

If you want to argue that, do science. I'll report on quality science
when it's presented. But global warming denialists have been involved
in a political exercise, just like those who deny evolution.
Discredit and destroy the scientists and ignore any facts that
contradict your worldview.

Science and politics are different. So the standards for reporting
each must also be different.
Posted by DanaBlankenhorn
29th Mar 2010
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