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Dairy cow produces hypoallergenic milk

By | October 3, 2012, 9:52 PM PDT

In a world’s first, researchers have genetically engineered a dairy cow to produce hypoallergenic milk that’s high in protein.

Some infants are allergic to a milk protein called beta-lactoglobulin (BLG), which is found in milk from cows but not from humans.

To help decrease BLG levels in milk, a team led by Goetz Laible from AgResearch in New Zealand first had to identify the protein’s genetic code.

They, using the code for BLG, they made a complimentary genetic structure that can shut down BLG production when injected into a cell. (The process of inhibiting the expression of certain genes is called RNA interference.)

They first tested the process in mice engineered to mimic the mammary gland of a sheep – resulting in a 96% reduction of BLG.

Then they transferred a treated nucleus into a cow egg cell, which was fertilized and implanted into a cow. From this, a healthy female calf was born (although without a tail, curiously).

When the researchers induced lactation in the calf, the milk produced contained high levels of protein and a dramatic reduction in BLG levels (compared with nonengineered calves).

The method might allow researchers to modify other properties of milk, such as levels of antibodies and hormones.

The work was published in the Proceedings of the National Academy of Sciences this week.

[Via New Scientist]

Image by Foxtongue via Flickr

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Janet Fang

About Janet Fang

Janet Fang is a contributing editor for SmartPlanet.

Janet Fang

Janet Fang
Contributing Editor, Healthcare

Janet Fang has written for Nature, Discover and the Point Reyes Light. She is currently a lab technician at Lamont-Doherty Earth Observatory. She holds degrees from the University of California, Berkeley and Columbia University. She is based in New York.

Follow her on Twitter.

Janet Fang

Janet Fang

Janet does not have financial holdings that would influence how or what she covers.

She writes for SmartPlanet and is not an employee of CBS.

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0 Votes
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It already exists...
It's called a Human Mother's Breast. While not always perfect, rather than CREATE problems, which transgenics have since they dropped the first "Round-Up Ready" seed into the ground in the 90's, they contain a cocktail of vitamins, nutrition, protein chains and immune markers genetically tailored for the infant human in question.

It seems we think we can always "one-up" Nature, even after over twenty years of evidence to the contrary.

So...do these Trans-Human cows have "souls"? I can't wait to hear the moshing over THAT one.
Posted by DrRexDexter
4th Oct
0 Votes
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"Although without a tail, couriously"
First they give us GMO's now we have GMC's (Genetically Modified Cows). One without a tail, maybe one without ears or feet or who knows. Of course I would just love to give this milk to my children, so their children could end up limbless or with some terrible new disease. Give me a break. When are we as a people going to stop this assault on mankind! Soylent Green or Zombie Apocalypse coming to a neighborhood near you.
Posted by foolmeonce
4th Oct
0 Votes
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Engineered Milk/Mice/Breasts, This is Crazy
Why do humans insist on continuing to drink the breast milk of another species? And continue to do so well past the stage of weening. Its not like this is the only source of fluid that we could drink for hydration.

Yes when I was a child in elementary school back in the 50's I was indoctrinated by the dairy/school/government/health industries that "Milk" is the perfect food. Well of course it is, for the first 6 months of life from your mother. But certainly not cow's milk, or for that matter, the milk of any other species. Dairy has become an institution that will take a long time if ever to dismantle. But for those who have educated themselves about the nature of "milk" in general, to live a healthy life, it is a better choice to avoid animal milks altogether and concentrate instead on the other alternative non-animal milks that are life enriching.
Posted by dcr100@...
4th Oct
0 Votes
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Ice Cream
Don't ask me to give up my ice cream!
Posted by riverat1
4th Oct
0 Votes
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re: incomplete reporting
If you look at other articles about this so called 'breakthrough' you'd discover that this GM milk is NOT allergen-free. In fact it increases the levels of another milk protein, casein. "Wagner says the absence of BLG has a strong effect on the composition of the milk, with greatly enhanced levels of other milk proteins, in particular casein. The higher levels of casein correlate with increased levels of calcium and improved cheese yields from the milk." So we come to the real reasons for the GM - making cheese, not saving children allergic to milk.

Casein is an allergen problem for a great many people including children. About 2% to 3% of babies will have a casein allergy. But an even greater number of adults are allergic to casein. So this is a case of GM solving one problem only to create more and bigger problems.
http://www.cbc.ca/news/technology/story/2012/10/02/genetically-modified-cow-allergy-free-mill.html

Similar to the controversy around the frankenfish 'salmon' the corporations involved do not seem to care that their GM creatures are MORE allergy producing than the non-modified creatures. The GM companies acknowledge that their creations generate a higher level of allergic reactions among populations but still claim that labeling of GM products is not needed. So if you have food allergies your food options are becoming ever more limited as companies seek to profit from their genetic tinkering.

As a person who has become intolerant to various products containing GM ingredients I am gradually feeling like an unloved endangered species. Splicing genes in a lab is not the same as selective breeding. Splicing genes in a lab is great science fiction but it makes for a food supply that is in no way more nutritious or healthier. It just makes the food supply more dangerous.

And by the way, no one in the USA is seriously testing for long-term safety of genetically modified foods, either plant or animal. The FDA say's it's the producers responsibility. The companies says it's the FDA's responsibility. So unless you drop dead immediately after eating, a food is deemed 'safe' or marketable.

Welcome to being a lab rat.
Posted by 2mtnplanner
4th Oct
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