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Beware the antibiotic apocalypse

By | January 25, 2013, 4:58 AM PST

Get a sore throat. Meet this guy.

There’s a dire warning coming out of the U.K. that makes global warming look like child’s play: Common infections are going to wipe us out, because bacteria is developing an insurmountable resistance to antibiotics and there is little current likelihood of successfully modifying existing drugs.

“There is a broken market model for making new antibiotics, so it’s an empty pipeline,” England’s chief medical officer, Prof Dame Sally Davies, told Parliament, as reported by the BBC yesterday.

With a sense of the grim reaper, Davies explained that bacterial bugs naturally develop resistance to the antibiotics that attack them, but the way we have used drugs - she has warned previously against overuse - has exacerbated that process. “As they become resistant…there will not be new antibiotics,” she said.

Davies warned two months ago that overuse of antibiotics is making them ineffective. Her language this time was indisputably ominous.

“The apocalyptic scenario is that when I need a new hip in 20 years I’ll die from a routine infection because we’ve run out of antibiotics,” she said. “It’s very serious because we are not using our antibiotics effectively.”

The World Health Organization concurs. “Many common infections will no longer have a cure and, once again, kill unabated,” it has said.

Hugh Pennington, a microbiology professor from the University of Aberdeen, shares those concerns. He called drug resistance “a very, very serious problem,” and noted that, “We have to be aware that we aren’t going to have new wonder drugs coming along because there just aren’t any.”

Among the diseases already flashing deadly fangs is gonorrhea, for which there is only one remaining antibiotic, chief medical officer Davies said. The story also singles out E.coli and tuberculosis.

But don’t take up residence in a plastic bubble quite yet. Davies will publish “possible solutions” in March.

Meanwhile, have a jolly weekend. For goodness sake though, don’t get a sore throat, and be careful when slicing vegetables.

Image: Iconwallstickers.co.uk

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Mark Halper

About Mark Halper

Mark Halper is a contributing editor for SmartPlanet.

Mark Halper

Mark Halper

Contributing Editor

Mark Halper has written for TIME, Fortune, Financial Times, the UK's Independent on Sunday, Forbes, New York Times, Wired, Variety and The Guardian. He is based in Bristol, U.K.

Follow him on Twitter.

Mark Halper

Mark Halper

Mark has no financial holdings in the companies he writes about. He occasionally travels at the expense of companies or their press relations agencies in order to report on a company or industry event related to it; Mark will prominently disclose this information when appropriate. This relationship will have no influence on his coverage. Companies he covers do not get to review columns in advance, or select or reject topics.

He writes for SmartPlanet and is not an employee of CBS.

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0 Votes
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Are the bacteria actually developing resistance...
or are the ones that are resistant the ones that the drugs didn't work against in the first place? Isn't this a case of only the strong survive? If there are 100 bacteria, and you kill off 96, because the last few are naturally resistant, wouldn't that leave the ones that are already resistant to be the ones that sire the next germs?
Posted by BrewmanNH
25th Jan
+1 Vote
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Are the bacteria actually developing resistance...
That is called evolution - survival of the fittest - as proposed and acknowledged by Darwin many decades previous. It is what is understood as 'developing resistance'.

Basically, when a majority of microbes is wiped out, the playing field is left to the survivors who can multiply freely to exploit it, thus generating a new majority population on which the drugs have little or no effect.

But this does not just relate to drugs and bacteria. A similar trend is surely happening with the use of silver anti-microbial materials in work surfaces, paint finishes and plastics and with domestic cleaners/disinfectants. These are all now so universally applied that their effects must be influencing the development of their targets too, by continuously weeding out the vulnerable life forms but always leaving that potentially devastating remnant.
Posted by peter.bessey@...
Updated - 25th Jan
+1 Vote
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Viruses are becoming impervious to anti-microbials as well
It's not just bacteria, but also viruses that are getting impervious to anti-microbials (of course, antibiotics never affected viruses). Just today I heard a report on the norovirus ( https://en.wikipedia.org/wiki/Norovirus ), which is a type of stomach flu which causes vomiting. It was responsible for the stomach flu outbreaks on several cruise ships. A strain of it has arisen which is impervious to hand sanitizers such as Purell. The only way to get rid of it on external surfaces is by washing your hands thoroughly with soap and water, and wiping down all exposed hard surfaces with chlorine bleach.
Posted by zackers
Updated - 29th Jan
+4 Votes
+ -
food related?
Is any of this related to the prevalence of antibiotics in our meat supply? No mention of that in this article. Perhaps the author could do a follow up article.
Posted by wally_altoona
25th Jan
+2 Votes
+ -
More grant and R&D bait.
Yes, bacteria do become resistant to anti-biotics and comparatively quickly, but what isn't mentioned is that they lose that resistance equally quickly if they aren't exposted to the respective antibiotic regularly. Bacteria and have new generations in 24 hrs. or less so adaptation can be very quick. However, when they aren't challenged by an anti-biotic for an extended period there is no reason to maintain the acquired resistance and it is diluted out by more useful genes.

You won't hear this because it doesn't suit big pharma and gov. needs. If there were indeed a terrible crisis regarding antibiotics the most simple and direct action would be to cycle the use of certain anti-biotics of anti-biotic families and allow the resistance to them by bacteria to be diluted out over time. Over the correct amount of time those anti-biotics would become effective again - until resistance was reacquired. Not seeing this happen means either our leadership is incredibly incompetent, or this is just more hype to justify more gov. expenditures to their favorite campaign donors.
Posted by dduggerbiocepts
25th Jan
0 Votes
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Antiobiotic resistance
The Russians had developed biological warfare during the cold war. They were able to crank out huge volumes of anthrax and other toxic nasties. They also learned how do do something else no one else seems to have mastered, something called phage therapy. From what little I understand about it is that for every virus and bacteria there are other agents which learn how to attack and kill them, these are called phages. It was common for a Russian citizen with a particular ailment to walk into a clinic, be diagnosed, and given a vial of mixture containing phages and soon the patient would be healed. This is something unheard of in this country but "was" common there during those times when they were researching biological warfare. They had the scientists/researchers who knew what they were doing. When the cold war ended the scientists were out of work and were let go. They had to go off in retirement or into some other field. Anyway, even Russia no longer has the science anymore to manage phage therapy. They tried to sell the technology to the American drug companies but those companies wanted to get it for free instead of spending a few millions to buy it. The Russians rightly told them to bug off, they weren't just giving it away, they hoped to be able to retire with a pile of rubles to make later life comfy. So that's where phage therapy is now. It worked well and it made bacterial and viral resistance to drugs a none issue. It's time western researchers got on the ball and pressed ahead with research into those ares as if we were facing germ warfare from another nation. We are, just that it's from the germs around us which have learned to rearm and attack.
Posted by radiodog4@...
25th Jan
-5 Votes
+ -
Try a better analogy next time, because, global warming is a farce
and an agenda item for liberal government leaders, and for "scientists" looking for government grants to keep them employed.
Posted by adornoe
25th Jan
0 Votes
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Balance of life, do not interfere !
Any life form is better than a dead fish... doc.
Posted by Elrandy
27th Jan
0 Votes
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It's only part of a bigger problem
Antibiotic resistance was recognized shortly after penicillin was developed. Disease has always ruled and now we see emergent and re-emergent diseases. Really it's only part of a bigger problem. Think of Eugenics. It's a big issue regardless of if it is considered morally unacceptable. It too is a part of that bigger problem. The only way to understand either is to describe it as a change in ecology, then you can solve both problems and a number of others you aren't aware of yet.
Posted by a1swdeveloper
7th Feb
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